Investigation of the role of nutrition and gut microbiome in well-being as well as in the etiology of disease and morbidity in humans
Gut microbiota, one of the most complex and dense microbial ecosystems, is recognized for its crucial role in human health. Imbalance in the dynamic interactions among intestinal microbial communities, a phenomenon called dysbiosis, has been related to many pathological conditions, such as inflammatory bowel disease, irritable bowel syndrome, obesity, and colorectal cancer. The modulation of Gut Microbiome (GM) through the consumption of functional foods can restore gut homeostasis and reverse leaky gut state. Recently, the development of advanced sequencing tools paved the way for significant breakthroughs in Gut Microbiome research while many studies have revealed the fundamental importance of the microbiome in shaping host immune responses.
Supported by and building on the FUNglucan project (2018-2022) and through applying holistic approaches such as NMR Metabolomics and Next Generation Sequencing, we aim at identifying dietary factors with enhanced prebiotic activity in view of the development of novel food products which promote health and quality of life, of the elderly in particular, through exploiting the Greek biodiversity. In vitro, in vivo, ex vivo as well as clinical intervention studies are being implemented.
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- Saxami, G., Kerezoudi, E.N., Mitsou, E.K., Koutrotsios, G., Zervakis, G.I., Pletsa, V., Kyriacou, A. Fermentation supernatants of pleurotus eryngii mushroom ameliorate intestinal epithelial barrier dysfunction in lipopolysaccharide-induced caco-2 cells via upregulation of tight junctions. Microorganisms 2021, 9.
- Vlassopoulou, M., Yannakoulia, M., Pletsa, V., Zervakis, G.I., Kyriacou, A. Effects of fungal beta-glucans on health-a systematic review of randomized controlled trials. Food Funct.2021, 12, 3366–3380.
- Boulaka, A.; Christodoulou, P.; Vlassopoulou, M.; Koutrotsios, G.; Bekiaris, G.; Zervakis, G.I.; Mitsou, E.K.; Saxami, G.; Kyriacou, A.; Zervou, M.; Georgiadis, P.; Pletsa, V. Genoprotective Properties and Metabolites of β-Glucan-Rich Edible Mushrooms Following Their In Vitro Fermentation by Human Faecal Microbiota. Molecules 2020, 25, 3554. https://doi.org/10.3390/molecules25153554
- Mitsou EK, Saxami G, Stamoulou E, Kerezoudi E, Terzi E, Koutrotsios G, Bekiaris G, Zervakis GI, Mountzouris KC, Pletsa V, Kyriacou A. Effects of Rich in Β-Glucans Edible Mushrooms on Aging Gut Microbiota Characteristics: An In Vitro Study. Molecules 2020, Jun 18;25(12):2806.
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