Institute of Chemical Biology - National Hellenic Research Foundation

About Team Collaborations Funding Publications

Main Scientific Directions

Dynamics, Stability and Phase Behavior of Colloids and Complex fluids
Colloids for Delivery of Bioactive compounds, Pharmaceutical applications
Colloids in Food Science and Technology
Scattering, Imaging and Microstructure

Research Activities

Colloidal nanodispersions as encapsulation and delivery vehicles of bioactive compounds (drugs, vitamins, pesticides, essential oils, antioxidants, enzymes, peptides)

Colloidal_nanodispersions

Colloidal delivery systems based on microemulsions and nanoemulsions have been the centre of discussion for many years due to their broad range of application from drug delivery to encapsulation of food ingredients and biocatalysis. Both systems are consisted of an aqueous phase dispersed to an oil one (and vice versa), in the presence of surfactants.

Microemulsions are isotropic, optically clear, thermodynamically stable, and spontaneously formed liquid mixtures of oil, water and surfactants. They are composed of nanometer-sized droplets usually ranging from 5 to 50 nm. Nanoemulsions are kinetically stable liquid-in-liquid dispersions with droplet sizes ranging from 50 to 500 nm. They are prepared using low-energy or high-energy emulsification approaches or a combination of both. Hybrid hydrogels are nanoemulsion-filled hydrogels consisting of a polymer gel matrix in which a nanoemulsion is incorporated.

Encapsulation is the process of entrapping a variety of active compounds within a protective carrier material. The process of encapsulating substances with various coating materials at the nanoscale range is called nanoencapsulation.

Selected Publications

Demisli, S., Chatzidaki, M.D., Xenakis, A., Papadimitriou, V. (2022). Recent progress on nano-carriers fabrication for food applications with special reference to olive oil-based systems. Curr. Opin. Food Sci, Volume 43, 146-154
Theochari, I., Mitsou, E., Nikolic, I., Ilic, T., Dobricic, V., Pletsa, V., Savic, S., Xenakis, A. and Papadimitriou, V. (2021). Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and bioperformances. J. Mol. Liq., 334, 116021.
Demisli, S., Mitsou, E., Pletsa, V., Xenakis, A., Papadimitriou, V. (2020). Development and study of nanoemulsions and nanoemulsion-based hydrogels for the encapsulation of lipophilic compounds. Nanomaterials, 10, 2464.
Demisli, S., Theochari, I., Christodoulou, P., Zervou, M., Xenakis, A., Papadimitriou, V. (2020). Structure, activity and dynamics of extra virgin olive oil-in-water nanoemulsions loaded with vitamin D3 and calcium citrate. J. Mol. Liq. 306.
Theochari, I., Giatropoulos, A., Papadimitriou, V., Karras, V., Balatsos, G., Papachristos, D., Michaelakis, A. (2020). Physicochemical Characteristics of Four Limonene-Based Nanoemulsions and Their Larvicidal Properties against Two Mosquito Species, Aedes albopictus and Culex pipiens molestus. Insects, 11, 740.
Chatzidaki, M.D., Balkiza, F., Gad, E., Alexandraki, V., Avramiotis, S., Georgalaki, M., Papadimitriou, V., Tsakalidou, E., Papadimitriou, K., Xenakis, A. (2019). Reverse micelles as nano-carriers of nisin against foodborne pathogens. Part II: The case of essential oils. Food Chem., 278, 415-423.
Golfomitsou, I., Mitsou, E., Xenakis, A., Papadimitriou, V. (2018). Development of food grade O/W nanoemulsions as carriers of vitamin D for the fortification of emulsion based food matrices: A structural and activity study. J.Mol. Liq., 268, 734-742.
Chaari, M., Theochari, I., Papadimitriou, V., Xenakis, A., Ammar, E. (2018). Encapsulation of carotenoids extracted from halophilic Archaea in oil-in-water (O/W) micro-and nano-emulsions. Colloids and Surfaces B: Biointerfaces, 161, 219-227
Chatzidaki, M.D., Papadimitriou, K., Alexandraki, V., Balkiza, F., Georgalaki, M., Papadimitriou, V., Tsakalidou, E., Xenakis, A. (2018). Reverse micelles as nanocarriers of nisin against foodborne pathogens. Food Chem., 255, 97-103.
Papanikolaou, N.E., Kalaitzaki, A., Karamaouna, F., Michaelakis, A., Papadimitriou, V., Dourtoglou, V., Papachristos, D.P. (2018). Nano-formulation enhances insecticidal activity of natural pyrethrins against Aphis gossypii (Hemiptera: Aphididae) and retains their harmless effect to non-target predators. Environ. Sci. Pollut. Res. 25, 10243-10249.
Theochari, I., Papadimitriou, V., Papahatjis, D., Assimomytis, N., Pappou, E., Pletsa, V. (2018). Oil-in-water microemulsions as hosts for benzothiophene-based cytotoxic compounds: An effective combination. Biomimetics, 3, 13.
Khemakhem, M., Sotiroudis, G., Mitsou, E., Avramiotis, S., Sotiroudis, T.G., Bouzouita, N., Papadimitriou, V. (2016) Melanin and humic acid -like polymer complex from olive mill wastewaters. Part II. Surfactant properties and encapsulation in W/O microemulsions. J. Mol. Liq. 222, 480-486
Chatzidaki, M., Papadimitriou, K., Alexandraki, V., Tsirvouli, E., Chakim, Z.,Ghazel, A. Mortensen, K., Yaghmur, A., Salentinig, S., Papadimitriou, V., Tsakalidou, E., Xenakis, A. (2016). Microemulsions as potential carriers of nisin: effect of composition on the structure and efficacy. Langmuir, 32, 8988-8998
Chatzidaki, M., N. Arik, J. Monteil, V. Papadimitriou, F. Leal-Calderon, A. Xenakis (2016). Microemulsion versus emulsion as effective carrier of Hydroxytyrosol. Colloids and Surfaces B. Biointerfaces (2016) 137, 146-151.
Kalaitzaki, A., Papanikolaou, N.E., Karamaouna, F., Dourtoglou, V., Xenakis, A., Papadimitriou, V. (2015) Biocompatible Colloidal Dispersions as Potential Formulations of Natural Pyrethrins: A Structural and Efficacy Study. Langmuir, 31, 5722-5730.
Chatzidaki, M., Mitsou, E., Yaghmur, A., Xenakis, A., Papadimitriou, V. (2015) Formulation and characterization of food-grade microemulsions as carriers ofnatural phenolic antioxidants. Colloids and Surfaces A: Physichochem. Eng. Aspects 483, 130-136
Kalaitzaki, A., Poulopoulou, M., Papadimitriou, V., Xenakis, A. (2014) Surfactant-rich biocompatible microemulsions for transdermal administration of methylxanthine drugs. Colloids and Surfaces A: Physichochem. Eng. Aspects. 442, 80-87
Kalaitzaki, A., Emo, M., Stébé, M.J., Xenakis, A., Papadimitriou, V. (2013) Biocompatible nanodispersions as delivery systems of food additives. Food Res International, 54, 1448-1454.

Book Chapters

Theochari, I., Xenakis, A., Papadimitriou, V. (2020). Nanocarriers for effective drug delivery. In Smart Nanocontainers (pp. 315-341). Elsevier.
Chatzidaki, M.D., Papadimitriou, V., Xenakis, A. (2019). Encapsulation of food ingredients by microemulsions. In Lipid-Based Nanostructures for Food Encapsulation Purposes (pp. 129-149). Academic Press.

Structural characterization of colloidal nanodispersions using analytical techniques based on scattering, spectroscopy, electrical conductivity and microscopy

StructuralCharacterisation_ColloidalNanodispersions

As the importance of nanocarriers in basic research and applications is constantly increasing, the reproducible and reliable characterization of nanomaterials, after their synthesis and during storage, is essential. Colloidal nanodispersions are evaluated in terms of size, size distribution, z-potential, shape, membrane dynamics, phase transition and viscosity applying instrumental techniques based on Electron Paramagnetic Resonance (EPR) spectroscopy, Dynamic Light Scattering (DLS), Small Angle X-ray Scattering (SAXS), Confocal Fluorescence Microscopy, Cryo-Electron Microscopy, Electrical Conductivity, Diffusion Ordered Nuclear Magnetic Resonance, and Viscometry.

Selected Publications

Demisli, S., Theochari, I., Christodoulou, P., Zervou, M., Xenakis, A., Papadimitriou, V. (2020). Structure, activity and dynamics of extra virgin olive oil-in-water nanoemulsions loaded with vitamin D3 and calcium citrate. J. Mol. Liq. 306. 112908
Kalogianni, E. P, Sklaviadis, L., Nika, S., Theochari, I., Dimitreli,G., Georgiou, D., Papadimitriou, V. (2017) Effect of oleic acid on the properties of protein adsorbed layers at water/oil interfaces: A study by EPR combined with dynamic interfacial properties. Colloids and Surfaces Β: Biointerfaces 158, 498-506
Gonçalves, K., I.I. Junior, V. Papadimitriou, M. Zoumpanioti, I.C.R., Leal, R.O.M.A. de Souza, Y. Cordeiro, A. Xenakis. (2016) Nanoencapsulated Lecitase Ultra and Thermomyces lanuginosus Lipase, a Comparative Structural Study. Langmuir 32, 6746-6756
Kalaitzaki, A., Xenakis, A., Papadimitriou, V. (2015). Highly Water Dilutable Microemulsions: A structural study. Colloid Polym.Sci. 293, 1111-1119
Papadimitriou, V., Dulle, M., Wachter, W., Sotiroudis, T.G., Glatter, O., Xenakis, A. (2013). Structure and dynamics of veiled virgin olive oil: Influence of production conditions and relation to its antioxidant capacity. Food Biophysics 8, 112-121
Fanun, M., Papadimitriou, V., Xenakis, A. (2011). Characterization of cephalexin loaded non-ionic microemulsions. J. Colloid Inter. Sci. 361, 115-121
Avramiotis, S., Papadimitriou, V., Hatzara, E., Bekiari, V., Lianos P., Xenakis, A. (2007). Lecithin Organogels Used as Bioactive Compounds Carriers. A Microdomain Properties Investigation. Langmuir 23, 4438-4447

Bioperformance of colloidal nanocarriers

In vitro biological evaluation of the colloidal nanocarriers using specific cell lines and approaches such as cell proliferation assays and flow cytometry

In vitro permeation studies to evaluate the ability of the colloidal nanocarriers to release the encapsulated bioactive compounds through skin or artificial membranes

Bioperformance_ColloidalNanodispersions

Selected Publications

Theochari, I., T. Ilic, T., Nicolic, I., Dobricic, V., Tenchiou, A., Papahatjis, D., S. Savic, S., Xenakis, A., Papadimitriou, V., Pletsa, V.*, (2021). Evaluation of Oil-In-Water Microemulsions as carriers of lipophilic, cytotoxic compounds for dermal applications. Biomimetics, 2021, 6, 10
Nikolic, I., Mitsou, E., Pantelic, I., Randjelovic, D., Markovic, B., Papadimitriou, V., Xenakis, A., Lunter, D.J., Zugic, A., Savic, S., (2020). Microstructure and biopharmaceutical performances of curcumin-loaded low-energy nanoemulsions containing eucalyptol and pinene: Terpenes’ role overcomes penetration enhancement effect. Eur. J. Pharm. Sci., 142, 105135.
Nikolić, I., Mitsou, E., Damjanović, A., Papadimitriou, V., Antić-Stanković, J., Stanojević, B., Xenakis, A., Savić, S., (2020). Curcumin-loaded low-energy nanoemulsions: Linking EPR spectroscopy-analysed microstructure and antioxidant potential with in vitro evaluated biological activity. J. Mol. Liq., 301. 2019
Pajic, N.B., Nikolic, I., Mitsou, E., Papadimitriou, V., Xenakis, A., Randjelovic, D., Dobricic, V., Smitran, A., Cekic, N., Calija, B., Savic, S., (2018). Biocompatible microemulsions for improved dermal delivery of sertaconazole nitrate: Phase behavior study and microstructure influence on drug biopharamaceutical properties. J. Mol. Liq., 272, 746-758.
Savić, V., Todosijević, M., Ilić, T., Lukić, M., Mitsou, E., Papadimitriou, V., Avramiotis, S., Marković, B., Cekić, N., Savic, S. Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances. Int. J. Pharmaceutics (2017) 529, 491-505.

Targets and Strategic plan

The group of Nanobiotechnology focuses on the development and characterization of biocompatible nanocarriers for the encapsulation, protection and effective delivery of various active components and their applications in the field of foods, pharmaceutics, agrochemicals, and cosmetics.

The strategic plan of the Nanobiotechnology group for the upcoming period includes:

Food fortiﬁcation with lipophilic/hydrophilic active compounds using edible nanocarriers

To be supported by the following research grant (submitted):
NanoFuncDairy: Development of edible nanocarriers for the encapsulation of bioactive ingredients from Greek goat and sheep milk to be used in the production of dairy products with health benefits. Regional Operational Programme Attica 2014-2020 (Partners: Pagonis Dairy Company, Laboratory of Dairy Research/AUA) (Co-coordinator ICB/NHRF).

Gelled non-toxic microemulsions for dermal delivery of lipophilic compounds

In collaboration with the research group of Prof. Dr. Cosima Stubenrauch, Institute of Physical Chemistry, University of Stuttgart, Stuttgart, Germany.

Development and structural characterization of pharmaceutical nanoemulsions and hydrogels as carriers of drugs for targeted therapies

To be supported by research grant in the context of NSRF “Competitiveness" Program for the new programming period 2021-2027 (to be submitted).

Scattering, Imaging and Microstructure

To be supported by the Recovery and Resilience Facility (RRF) funding (€30,7) of the NHRF to further enhance research capacity and its contribution to core areas of science and technology.

The above-mentioned activities aim to attract high-quality young scientists (post-doctoral researchers, PhD candidates) to contribute to the Institute’s strong research profile. Their participation in the research projects will help them expand their research horizons, maintain contact with the Greek and international scientific community and be better prepared for their scientific professional career.

Training and Educational Activities

Teaching Activities

Bioenterpreneurship (2015-present): Lecturer in the course “Food and Nutrition: Application of nanotechnology in food science” in the frame of the interdepartmental, interdisciplinary Master’s programme “Bioenterpreneurship” organized by the University of Thessaly (UTh) and the ICB/NHRF (Greece). Also member of the Interdepartmental and Coordination Committee.

Oncology (2019-present): Lecturer in the course “Nanosystems for drug delivery” in the frame of the interdepartmental, postgraduate Master’s programme “Oncology” organized by the University of Crete and the ICB/NHRF (Greece).

Food Science and Technology, Food Processing, Preservation and Innovation (2014-2019): Lecturer in the course “Application of nanotechnology in food science” and “Food dispersions” in the frame of the Master’s programme “Food Science and Technology, Food Processing, Preservation and Innovation” organized by the Department of Food Technology, University of West Attica (Greece).

Supervision of undergraduate, graduate students and postdoctoral fellows

Postdoctoral fellows

2018-2022: Dr. Maria Chatzidaki, PhD, Chemical Engineer
2018-2020: Development of microemulsions. Nanoencapsulation of existing and new plant insect repellents and their physicochemical characterization. Preparation of moisturizing emulsions
2020-present: Application of nanotechnology for the development of sunscreens using natural extracts

PhD students

2018-present: Demisli Sotiria, MSc. Chemist, Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
Title: Development of nanodispersions for the encapsulation on cannavinoids and other bioactives
The main aim of the thesis is the development of oil-in-water nanodispersions using biocompatible ingredients for the encapsulation of vitamins, cannabinoids, essential oils and their combination with natural polymer hydrogels. The systems are structurally characterized by Dynamic Light Scattering, Electron Paramagnetic Resonance spectroscopy, SAXS, confocal microscopy and Cryo EM, before and after the encapsulation of the bioactive compounds. Structural characterization is of great importance as these factors influence the behavior of the systems and their effective delivery on skin and the epithelium.

2018-present: Ines Nicolic, PhD student, Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Title: Nanoemulsions prepared via spontaneous emulsification for dermal application of curcumin: investigation of the interfacial phenomena in the colloidal system and their impact on delivery efficiency and biological activity
The overall goal of this thesis is to develop low energy nanoemulsions for enhanced dermal delivery of curcumin, understanding the complex interactions underlying these colloidal systems which have not been fully explored so far. In parallel, certain aspects of physical and chemical modalities to improve the delivery of active ingredients into/through the skin will be considered, with the idea to design a prototype of an innovative adhesive patch for dermal application that will be based on a combination of electrical energy. The general goal is to provide significantly improved dermal availability of the active ingredient with the synergistic effects of 2 strategies, using curcumin as a model active ingredient, and to potentially apply the proposed approach to other poorly soluble molecules. Finally, improvement of patient compliance in the field of dermal drug administration is expected

2020-present: Galani Eleni, MSc. Chemist, Department of Food Science and Human Nutrition, Agricultural University of Athens (AUA), Athens, Greece
Title: Incorporation of natural bioactive components into matrices to enhance food functionality and shelf-life
The aim of the thesis is the formulation of biocompatible nanodispersions for food applications. Natural bioactive components such as antioxidants, herbal extracts, antimicrobial agents, and probiotics will be encapsulated into matrices to improve food products’ nutritional value and shelf- life. Antioxidant capacity, antimicrobial efficiency, and stability of the encapsulated compounds will be studied. Structural characteristics will be studied using DLS, EPR, SAXS etc. Samples antioxidant capacity will be evaluated using various techniques. Well Diffusion Assay technique will contribute to the study of the systems’ antimicrobial effect against a plethora of pathogens commonly found in food.

2016-2020: Ioanna Theochari, MSc. Chemist, Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece

Title: Development of nanodispersions as carriers for bioactive compounds and their biological applications
The main object of this study was the formulation of nanodispersions, as carriers of bioactive compounds and their biological evaluation as potent delivery systems. Two types of nanodispersions, namely micro- and nanoemulsions were formulated and structurally characterized, performing different methods. The nanodispersions were used as matrices for the encapsulation of bioactive compounds with pharmacological interest such as chemotherapeutic and anti-inflammatory agents.

2015-2019: Evgenia Mitsou, Biologist, Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece
Title: Development of microemulsions for the administration of bioactive compounds.
The aim of the thesis was the formulation of biocompatible microemulsions based mainly on natural oils and biocompatible surfactants to serve as hosts for the encapsulation of natural bioactive compounds of therapeutic interest. Oral and nasal routes of administration were studied to exploit the multi-functional nature of the formulated colloidal dispersions.

MSc students

2021-present: Lambrini Pantazi, Food Technologist, “Bioenterpreneurship” University of Thessaly and ICB/NHRF
Title: Comparative study of the combination of statins with Ezetimibe. Pharmacological study and market analysis of the new product.
2019-2021: Makaronis Vasilios, Chemist, Master’s degree, University of Ionnina, Department of Chemistry, Ioannina, Greece
Title: Encapsulation of thiols in water in oil microemulsions for use in oils and fatty foods.
2020-2021: Panagiota Hachlaki, Biologist, Master’s degree in “Bioenterpreneurship” University of Thessaly and ICB/NHRF
Title: Co-encapsulation strategies of nutraceuticals and chemotherapeutic agents in nanocarriers for cancer treatment
2018-2019: Vassiliki Pliatsika, Chemical Engineer, Master’s degree in “Bioenterpreneurship” University of Thessaly and ICB/NHRF
Title: Feasibility Study for the Development of Plant-Based Non-Dairy Milk Product Enriched with Vitamin D Using Nanotechnology Methods
2016-2018: Olga Ventouri, Food Technologist, Master’s degree in “Bioenterpreneurship” University of Thessaly and ICB/NHRF
Title: Nanotechnology applications in the food sector. Preliminary Feasibility study for the development of a new honey-based product
2017-2018: Sotiria Demisli, Chemist, Master’s degree in “Bioenterpreneurship” University of Thessaly and ICB/NHRF
Title: Food supplement based on high-phenolic extra virgin olive oil using nanotechnology
2016-2017: Ioanna Theochari, Chemist, Master’s degree in “Bioenterpreneurship” University of Thessaly and ICB/NHRF
Title: Biocompatible nanodispersions for application in fish farms and feasibility study for new product development
2016-2017: Ioanna Golfomitsou, Chemist, Master’s degree in Food Science and technology, Food Processing, Preservation & Innovation, Technological Education Institute of Athens, Department of Food Technology.
Title: Development of edible nanodispersions for the encapsulation of hydrophobic bioactive substances
2013-2015: Leandros Sklaviadis, Food Scientist, MSc in Quality Management and Production Organization Systems for The Food Industry, International Hellenic University, Thessaloniki
Title: Study of the interaction of free fatty acids with proteins in oil-water interfaces using Electron Paramagnetic Resonance (EPR) spectroscopy

Undergraduate Students

2022: Anastasios Manoudakis, Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
Title: Development of biocompatible nanodispersions for the encapsulation of hydrophobic kinase inhibitors

2022: Katerina Skiada, Department of Biological Applications and Technology, University of Ioannina, Ioannina, Greece
Title: Biological evaluation of gelled nanoemulsions as delivery agents of bioactive substances for use in cosmetics, medicines, and food

2021: Spiridoula Arapi, Department of Food Science and Human Nutrition, Agricultural University of Athens (AUA), Athens, Greece
Title: Encapsulation of vitamin D3 in nanoemulsions
2020: Korogianni Elisavet, National Technical University of Athens (NTUA), Athens, Greece
Title: Encapsulation of bioactive compounds in nanodispersions

Visiting Researchers

2021: Jelena Djokovic, PhD student, Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Activity: EPR analysis of PEGylated nanoemulsions loaded with curcumin

2018: Ines Nicolic, PhD student, Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
Activity: An insight to interface properties of low-energy nanoemulsions for curcumin dermal delivery using electron paramagnetic resonance spectroscopy - a link with release kinetics and biological activity

Group Structure and Personnel

Vassiliki Papadimitriou, Group Leader, Senior Researcher
Georgios Sotiroudis, Scientific Technical personnel

Postdoctoral Researchers
Maria Chatzidaki, PhD

PhD students
Sotiria Demisli, Chemist
Eleni Galani, Chemist
Ioanna Theochari, Chemist
Evgenia Mitsou, Biologist

MSc students
Vassilios Makaronis, Lambrini Pantazi, Panagiota Hachlaki, Vicky Pliatsika, Olga Ventouri

Undergraduate students
Anastasios Manoudakis, Katerina Skiada, Spiridoula Arapi, Elisavet Korogianni

Visiting Researchers
Jelena Djokovic, PhD student
Ines Nicolic, PhD student

Collaborations

Prof. Otto Glatter, Department of Chemistry, University of Graz (Austria)
Prof. Ep. Leondidis, Chemistry Dept. University of Cyprus, Nicosia (Cyprus)
Prof. Fernando Leal Calderon, ENSBCP, INP, Université de Bordeaux (France)
Dr. Frederic Nallet, Centre de Recherches Paul Pascal - CRPP, Univ. Bordeaux (France)
Dr. Panagiotis Kastritis, Martin Luther University Halle-Wittenberg, Halle (Germany)
Prof. Cosima Stubenrauch, Institute of Physical Chemistry, University of Stuttgart, Stuttgart, (Germany)
Prof. Fabio Sonvico, Department of Pharmacy, University of Parma, Parma (Italy)
Prof. Snezana Savic, Faculty of Pharmacy, University of Belgrade (Serbia)
Prof. Milan R. Nikolic, Department of Biochemistry & Centre of Excellence for Molecular Food Sciences, University of Belgrade - Faculty of Chemistry, Belgrade (Serbia)
Dr. Vladimir Dobricic, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade (Serbia)
Prof. Emna Ammar, University of Sfax, US National School of Engineering of Sfax (ENIS) (Tunisia)
Prof. Dganit Danino, Faculty of Biotechnology & Food Engineering, Technion-Israel, Institute of Technology, Technion, Haifa, (Israel)
Prof. M. Fanun, Colloids and Surfaces Research Center, Al-Quds University 51000 East Jerusalem (Palestine)
Prof. Nabiha Bouzouita, Ecole Supérieure des Industries Alimentaires de Tunis, (Tunisia)
Prof. Tanja Cirkovic Velickovic, Faculty of Chemistry, University of Belgrade (Serbia)
Prof. Ivana C. R. Leal, and Prof. Yraima Cordeiro, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro (Brazil)
Prof. E. Tsakalidou, Agricultural University of Athens, Athens (Greece)
Prof. C. Stamatis, Department of Biological Applications & Biotechnology, University of Ioannina, Ioannina (Greece)
Prof. I. Roussis, Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, Ioannina (Greece)
Prof. D. Leonidas, Department of Biochemistry and Biotechnology, University of Thessaly, Larissa (Greece)
Dr. A. Michaelakis, Department of Entomology and Agricultural Zoology Benaki Phytopathological Institute, Kifissia (Greece)
Prof. V. Sinanoglou, Department of Food Science and Technology, University of West Attica (Greece)
Prof. G. Sotiropoulou, School of Health Sciences · Pharmacy, University of Patras (Greece)
Prof. P. Zoumpoulakis, Department of Food Science and Technology, University of West Attica (Greece)

Collaboration with Industries

Product development through common projects (food products, insect repellent, cosmetics biopesticides, etc.)

APIVITA, JOTIS SA, VIORYL SA, Public Power Corporation (ΔΕΗ), PAGONIS DAIRY, CLEANWAY Ltd., KRIKRI SA, QUALIA PHARMA, theraCell, Ekati lab, ELAIS-UNILEVER HELLAS SA, ΜΙΝΕRVΑ SA, ELAIOURGIKI, PEZA UNION, MIRABELLO UNION, SITIA UNION, MYLOPOTAMOS UNION, GAEA

Funding

STHENOS-b: Targeted therapeutic approaches against degenerative diseases with special focus on cancer and ageing-optimisation of the targeted bioactive molecules, MIS 5002398, Developmental Projects of Research Organisations- Kripis, NSRF. Role: Partner, Team budget 22,000 €, (01/11/2017-30/06/2021).

QFytoTera: Nanoemulsions of plant oils with moisturizing and insect repellent properties. Operational Program Competitiveness, Entrepreneurship and Innovation EPAnEK-NSRF (ΕΣΠΑ) 2014-2020 for collaborative R&D projects between academic institutions and the private sector (ΕΥΔΕ-ΕΤΑΚ Τ1ΕΔΚ-00996), Role: Partner/ WP1 leader, Team budget 96,630 €, (09/07/2018-08/07/2021 extension 08/07/2022).

CO2-BioProducts: Bioconversion of CO2 into high added value bioproducts through sustainable microalgae cultivation processes, MIS 5031682, Operational Program Competitiveness, Entrepreneurship and Innovation EPAnEK-NSRF (ΕΣΠΑ) 2014-2020, Role: Partner, Team budget 50.000 €, (25/07/2018-24/07/2021 extension 24/06/2022).

Nano-UV-Extracts: Application of nanotechnology for the development of sunscreens using natural extracts. Operational Program Competitiveness, Entrepreneurship and Innovation EPAnEK-NSRF (ΕΣΠΑ) 2014-2020, Role: Partner, Team Budget 50.000 €, (01/10/2020-27/01/2023).

INSTRUCT-EL hub/INSPIRED. A National Research Infrastructure on Integrated Structural Biology, drug screening efforts and drug target functional characterization. Strengthening Research and Innovation Infrastructures 2014-2020 (EPAnEK), Role: Partner, (03/09/2018-03/09/2021 extension 30/09/2022).

BeNeFIC: Application of Nanoemulsion Technology to food products based on Oil in Water Emulsions such as vegetable cream and fudge icings. National Strategic Reference Framework program (NSRF 2007-2013) PAVET “Budget: 300.000,00€ Contractor: JOTIS SA (Budget NHRF: 61.250€) (Coordinator NHRF, Dr. Vassiliki Papadimitriou).

NanoBioEnviro: Development of nanoemulsions as new materials for managing phytoprotective products to reduce the environmental charge. National Strategic Reference Framework (NSRF), Cooperation, Action I, 2010-2013, research programme Budget: 449.040,00€ (Budget NHRF 147.743€). (Coordinator Dr. Vassiliki Papadimitriou).

Quality and stability of virgin olive oil. The role of endogenous enzymes and antioxidants -biotechnological applications. Operational Program Competitiveness and Entrepreneurship, Cyprus-Hellenic Collaboration 2006-8. Budget NHRF: 11.740,00€. (Greek Coordinator Dr. Vassiliki Papadimitriou).

STHENOS: Targeted therapeutic approaches against degenerative diseases, with special focus on cancer and ageing. Program National Strategic Reference Framework, Action Developmental Projects of Research Organisations- Kripis2013-2015: Budget: 1.500.000,00€ (Biomimetics 174.773€). Role: partner. Coordinator Dr. A. Pintzas.

Micro/nano-émulsions de type e/h biocompatibles et riches en micronutriments: préparation et caractérisation. Program Agence Nationale de Recherche (ANR), Institut Carnot, Projet Lipides pour l’industrie et la santé (LISA), France. 2013-14. (Budget: 43.000€). Coordinator: F. Calderon, INP Bordeaux.

Nanobiotechnology. Lipase activity. Program CAPES, Ministry of Education, Brazil. 2010-2014. Budget: NHRF 40.000€.

Biocatalysis by immobilized enzymes in mesoporous materials for the biotechnological production of high added value products. Operational Program Competitiveness and Entrepreneurship, Franco-Hellenic Collaboration 2006-2007. Budget: 12.400,00€.

Determination of the most significant and usual quality problems encountered in greek olive oils. Evaluation and therapeutic actions. Program ''Cooperation'' of the Dir.1334/02 - ELAIOURGIKI - ΟΠΕΚΕΠΕ (2003-2004) Budget 20.000,00€

Study of parameters affecting the quality of greek virgin olive oils. Degree of maturity and natural antioxidants content. Program ''CRETE - ΣΥΝΕΡΓΑΣΙΑ'' of the Dir.1334/02 - Sitia, Mirampelo, Peza and Milopotamos Unions- ΟΠΕΚΕΠΕ (2004-2005) Budget 29.759,52€ Role: Partner.

Study of the presence and bioavailability of phenolic antioxidants in foods of the Mediterranean diet. Program ΕΠΕΤ ΙΙ - Subprogram 1, Action 2.3, Nutrition Program 97ΔΙΑΤΡΟ-29 (1999-2001) Contract with: Univ. of Thessaloniki Budget: 95.000.000 Grd (NHRF 17.450.000 Grd.)

Polyphenols and their polymers (tannins) in virgin olive oil and olive oil waste waters. Antioxidant action and free radical mechanism. The biotechnological importance for health, food and environment. Program ΕΠΕΤ ΙΙ - ΠΕΝΕΔ 99ΕΔ33 (1999-2001)

Structure-function lipase relationships in low water media. Program BIOTECH of the European Union (1994-1996) (in collaboration with Prof. F.N. Kolisis): " Budget: 55.000 ECU.

Enzymic studies in microemulsions. Structural aspects. Program PLATON 1993. (16th Collaboration protocol). Budget: 2.000.000 Grd.

Enzymic studies in microemulsions. Structural aspects. Program PLATON 1992. (Contract N 02001910092- 15th Collaboration protocol). Budget: 2.000.000Grd.

Publications

International Journals

Demisli, S., Chatzidaki, M.D., Xenakis, A., Papadimitriou, V. *, (2022). Recent progress on nano-carriers fabrication for food applications with special reference to olive oil-based systems. Curr. Opin. Food Sci, 43, 146-154 (IF 6.031)
Theochari, I., Mitsou, E., Nikolic, I., Ilic, T., Dobricic, V., Pletsa, V., Savic, S., Xenakis, A., Papadimitriou, V.*, (2021). Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and bioperformances. J. Mol. Liq., 334, 116021. (IF 6.165)
Gligorijević, N., Minić, S., Radibratović, M., Papadimitriou, V., Nedić, O., Sotiroudis, T.G., Nikolić, M.R.*, (2021). Nutraceutical phycocyanobilin binding to catalase protects the pigment from oxidation without affecting catalytic activity. Spectrochimica Acta Part A: Mol. Biomol. Spectrosc. 251, 119483. (IF 4.098)
Theochari, I., T. Ilic, T., Nicolic, I., Dobricic, V., Tenchiou, A., Papahatjis, D., S. Savic, S., Xenakis, A., Papadimitriou, V., Pletsa, V.*, (2021). Evaluation of Oil-In-Water Microemulsions as carriers of lipophilic, cytotoxic compounds for dermal applications. Biomimetics, 6, 10. (IF 2.69)
Demisli, S., Mitsou, E., Pletsa, V., Xenakis, A., Papadimitriou, V.*, (2020). Development and study of nanoemulsions and nanoemulsion-based hydrogels for the encapsulation of lipophilic compounds. Nanomaterials, 10, 2464. (IF 4.921)
Demisli, S., Theochari, I., Christodoulou, P., Zervou, M., Xenakis, A., Papadimitriou, V.*, (2020). Structure, activity and dynamics of extra virgin olive oil-in-water nanoemulsions loaded with vitamin D3 and calcium citrate. J. Mol. Liq. 306. (IF 6.165)
Theochari, I., Giatropoulos, A., Papadimitriou, V., Karras, V., Balatsos, G., Papachristos, D., Michaelakis, A., (2020). Physicochemical Characteristics of Four Limonene-Based Nanoemulsions and Their Larvicidal Properties against Two Mosquito Species, Aedes albopictus and Culex pipiens molestus. Insects, 11, 740. (2.139)
Nikolic, I., Mitsou, E., Pantelic, I., Randjelovic, D., Markovic, B., Papadimitriou, V., Xenakis, A., Lunter, D.J., Zugic, A., Savic, S., (2020). Microstructure and biopharmaceutical performances of curcumin-loaded low-energy nanoemulsions containing eucalyptol and pinene: Terpenes’ role overcomes penetration enhancement effect. Eur. J. Pharm. Sci., 142, 105135. (IF 4.384)
Nikolić, I., Mitsou, E., Damjanović, A., Papadimitriou, V., Antić-Stanković, J., Stanojević, B., Xenakis, A., Savić, S., (2020). Curcumin-loaded low-energy nanoemulsions: Linking EPR spectroscopy-analysed microstructure and antioxidant potential with in vitro evaluated biological activity. J. Mol. Liq., 301, 112479 (IF 6.165)
Chatzidaki, M.D., Balkiza, F., Gad, E., Alexandraki, V., Avramiotis, S., Georgalaki, M., Papadimitriou, V., Tsakalidou, E., Papadimitriou, K., Xenakis, A., (2019). Reverse micelles as nano-carriers of nisin against foodborne pathogens. Part II: The case of essential oils. Food Chem., 278, 415-423 (IF 7.514)
Golfomitsou, I., Mitsou, E., Xenakis, A., Papadimitriou, V.*, (2018). Development of food grade O/W nanoemulsions as carriers of vitamin D for the fortification of emulsion based food matrices: A structural and activity study. J.Mol. Liq., 268, 734-742 (IF 6.165)
Chaari, M., Theochari, I., Papadimitriou, V., Xenakis, A., Ammar, E., (2018). Encapsulation of carotenoids extracted from halophilic Archaea in oil-in-water (O/W) micro-and nano-emulsions. Colloids and Surfaces B: Biointerfaces, 161, 219-227 (IF 5.268)
Pajic, N.B., Nikolic, I., Mitsou, E., Papadimitriou, V., Xenakis, A., Randjelovic, D., Dobricic, V., Smitran, A., Cekic, N., Calija, B., Savic, S., (2018). Biocompatible microemulsions for improved dermal delivery of sertaconazole nitrate: Phase behavior study and microstructure influence on drug biopharamaceutical properties. J. Mol. Liq., 272, 746-758 (IF 6.165)
Chatzidaki, M.D., Papadimitriou, K., Alexandraki, V., Balkiza, F., Georgalaki, M., Papadimitriou, V., Tsakalidou, E., Xenakis, A., (2018). Reverse micelles as nanocarriers of nisin against foodborne pathogens. Food Chem., 255, 97-103 (IF 7.514)
Papanikolaou, N.E., Kalaitzaki, A., Karamaouna, F., Michaelakis, A., Papadimitriou, V., Dourtoglou, V., Papachristos, D.P., (2018). Nano-formulation enhances insecticidal activity of natural pyrethrins against Aphis gossypii (Hemiptera: Aphididae) and retains their harmless effect to non-target predators. Environ. Sci. Pollut. Res. 25, 10243-10249 (IF 4.223)
Theochari, I., Papadimitriou, V., Papahatjis, D., Assimomytis, N., Pappou, E., Pletsa, V., (2018). Oil-in-water microemulsions as hosts for benzothiophene-based cytotoxic compounds: An effective combination. Biomimetics, 3, 13 (IF 2.69)
Theochari, I., Goulielmaki, M., Danino, D., Papadimitriou, V.*, Pintzas, A., Xenakis, A. Drug nanocarriers for cancer chemotherapy based on microemulsions: the case of Vemurafenib analog PLX4720. (2017). Colloids and Surfaces Β: Biointerfaces 154, 350-356 (IF 5.268)
Savić, V., Todosijević, M., Lukić,T.M., Mitsou, E., Papadimitriou, V., Avramiotis, S., Marković, B., Cekić, N., Savić, S. (2017). Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances. Int. J Pharm. 529, 491-505 (IF 5.875)
Kalogianni, E.P., Sklaviadis, L., Nika, S., Theochari, I., Dimitreli, G., Georgiou, D., Papadimitriou, V*. (2017). Effect of oleic acid on the properties of protein adsorbed layers at water/oil interfaces: A study by EPR combined with dynamic interfacial properties. Colloids and Surfaces Β: Biointerfaces 158, 498-506 (IF 5.268)
Mitsou, E., Tavantzis, G., Sotiroudis, G., Ladikos, D., Xenakis, A., Papadimitriou, V*. (2016). Food grade water-in-oil microemulsions as replacement of oil phase to help process and stabilization of whipped cream. Colloids and Surfaces A: Physicochemical and Engineering Aspects 510, 69-76. (IF 4.539)
Khemakhem, M., Papadimitriou, V*., Sotiroudis, G., Zoumpoulakis, P., Arbez-Gindre, C., Bouzouita, N., Sotiroudis, T. G. (2016). Melanin and Humic acid-like polymer complex from olive mill waste waters. Part I. Isolation and Characterization. Food Chem. 203, 540–547. (IF 7.514)
Khemakhem, M., Sotiroudis, G., Mitsou, E., Avramiotis, S., Sotiroudis, T . G., Bouzouita, N., Papadimitriou, V*. (2016). Melanin and humic acid -like polymer complex from olive mill waste waters. Part II. Surfactant properties and encapsulation in W/O microemulsions. J. Mol. Liq. 222, 480-486 (IF 6.165)
Chatzidaki, M., Papadimitriou, K., Alexandraki, V., Tsirvouli, E., Chakim, Z., Ghazel, A. Mortensen, K., Yaghmur, A., Salentinig, S., Papadimitriou, V., Tsakalidou, E., Xenakis, A. (2016). Microemulsions as potential carriers of nisin: effect of composition on the structure and efficacy. Langmuir 32, 8988-8998 (IF 3.882)
Gonçalves, K., I.I. Junior, Papadimitriou, V., Zoumpanioti, M., I.C.R., Leal, R.O.M.A. de Souza, Y. Cordeiro, Xenakis, A (2016). Nanoencapsulated Lecitase Ultra and Thermomyces lanuginosus Lipase, a Comparative Structural Study. Langmuir 32, 6746-6756 (IF 3.882)
Chatzidaki, M., Arik, N., Monteil, J., Papadimitriou, V., Leal-Calderon, F., Xenakis, A. (2016). Microemulsion versus emulsion as effective carrier of Hydroxytyrosol. Colloids and Surfaces B: Biointerfaces 137, 146-151 (IF 5.268)
Kalaitzaki, A., Papanikolaou, N.E., Karamaouna, F., Dourtoglou, V., Xenakis, A., Papadimitriou, V*. (2015). Biocompatible Colloidal Dispersions as Potential Formulations of Natural Pyrethrins: A Structural and Efficacy Study. Langmuir, 31, 5722-5730 (IF 3.882)
Chatzidaki, M., Mitsou, E., Yaghmur, A., Xenakis, A., Papadimitriou, V*. (2015). Formulation and characterization of food-grade microemulsions as carriers of natural phenolic antioxidants. Colloids and Surfaces A: Physichochem. Eng. Aspects 483, 130-136 (IF 4.539)
Kalaitzaki, A., Xenakis, A., Papadimitriou, V*. (2015) Highly Water Dilutable Microemulsions: A structural study. Colloid Polym.Sci. 293, 1111-1119 (IF 1.931)
Sereti, V., Zoumpanioti, M., Papadimitriou, V., Pispas, S., Xenakis, A. (2014). Biocolloids Based on Amphiphilic Block Copolymers as a Medium for Enzyme Immobilization. J. Phys. Chem. B 118, 9808 – 9816 (IF 2.781)
Kalaitzaki, A., Poulopoulou, M., Papadimitriou, V*., Xenakis, A. (2014). Surfactant-rich biocompatible microemulsions for transdermal administration of methylxanthine drugs. Colloids and Surfaces A: Physichochem. Eng. Aspects 442, 80-87 (IF 4.539)
Kalaitzaki, A., Emo, M., Stébé, M. J., Xenakis, A., Papadimitriou, V*. (2013). Biocompatible nanodispersions as delivery systems of food additives. Food Res. Int. 54, 1448-1454. (IF 6.475)
Kyriazi, Α., Papadimitriou, V*., Sotiroudis, T. G., Xenakis. A. (2013). Development and characterization of a digestion model based on olive oil microemulsions. Eur. J. Lipid Sci. Technol., 115, 601-611 (IF 2.46)
Papadimitriou, V., Dulle, M., Wachter, W., Sotiroudis, T.G., Glatter, O., A. Xenakis, A. (2013) Structure and dynamics of veiled virgin olive oil: Influence of production conditions and relation to its antioxidant capacity. Food Biophysics, 8, 112-121 (IF 3.114)
Fanun, M., Papadimitriou, V*, Xenakis, A. (2011). Characterization of cephalexin loaded non-ionic microemulsions. J. Colloid Inter. Sci. 361, 115-121 (IF 8.128)
Tzika, E.D., M. Christoforou, S. Pispas, M. Zervou, Papadimitriou, V., T.G. Sotiroudis, Leontidis, E., Xenakis, A. (2011). Influence of nanoreactor environment and substrate location on the activity of horseradish peroxidase in olive oil-based w/o microemulsions. Langmuir, 27, 2692–2700 (IF 3.882)
Papadimitriou, V., Tzika, E.D., Pispas, S., Sotiroudis, T.G., Xenakis, A. (20111) Microemulsions based on virgin olive oil: a model biomimetic system for studying native oxidative enzymatic activities”. Colloids and Surfaces A: Physichochem. Eng. Aspects 382, 232-237, (IF 4.539)
Xenakis, Α. Papadimitriou, V., Sotiroudis, T.G. (2010). Colloidal structures in natural oils. Curr. Opin .Colloid Interface Sci. 15, 55-60 (IF 6.448)
Tzika, E.D., Sotiroudis, T.G., Papadimitriou, V., Xenakis, A. (2009) Partial purification and characterization of peroxidase from olives (olea europaea cv. Koroneiki)” Eur. Food Res Technol., 228, 487-495 (IF 2.998)
Papadimitriou, V*., Pispas, S., Syriou, S., Pournara, A., Zoumpanioti, M., Sotiroudis, T., Xenakis, A. (2008) Biocompatible microemulsions based on Limonene: Formulation, Structure and Applications. Langmuir, 23, 3380-3386. (IF 3.882)
Tzika, E.D., Papadimitriou, V*., Sotiroudis, T.G., Xenakis, A. (2008) Oxidation of oleuropein studied by ΕPR and spectrophotometry”. Eur. J. Lipid Sci. Technol. 110, 149-157 (IF 2.46)
Tzika, E.D, Papadimitriou, V*., Sotiroudis, T.G., Xenakis, A (2008) Antioxidant Properties of Fruits and Vegetables Shots and Juices: An Electron Paramagnetic Resonance Study. Food Biophysics, 3, 48-53 (IF 3.114)
Avramiotis, S., Papadimitriou, V., Hatzara, E., Bekiari, V., P. Lianos, P., Xenakis, A (2007) Lecithin Organogels Used as Bioactive Compounds Carriers. A Microdomain Properties Investigation. Langmuir, 23, 4438-4447 (IF 3.882)
Papadimitriou, V., Sotiroudis, T.G., Xenakis, A (2007) Olive Oil Microemulsions: Enzymatic Activities and Structural Characteristics. Langmuir, 23, 2071-2077 (IF 3.882)
Papadimitriou, V*., Sotiroudis, T.G., Xenakis, A., Sofikiti, N., Stavyiannoudaki, V., Chaniotakis, N.A. (2006). Oxidative stability and radical scavenging activity of extra virgin olive oils by using Electron Paramagnetic Resonance spectroscopy. Analytica Chimica Acta, 573-574, 453-458 (IF 6.558)
Zoumpanioti, M., Stamatis, H., Papadimitriou, V., A. Xenakis, A. (2006) Spectroscopic and catalytic studies of lipase in ternary hexane-1-propanol water surfactantless microemulsion systems”. Colloids Surfaces B: Biointerfaces, 47, 1-9 (IF 5.268)
Papadimitriou, V., G.A. Maridakis, T.G. Sotiroudis, A. Xenakis. (2005) Antioxidant activity of polar extracts from olive oil and olive mill wastewaters: an EPR and photometric study. Eur. J. Lipid Sci. Technol., 107, 513-520 (IF 2.46)
Papadimitriou, V., Sotiroudis, T.G., Xenakis, A. (2005). Olive oil microemulsions as a biomimetic medium for enzymatic studies. Oxidation of oleuropein. J. Am. Oil Chem. Soc., 82, 1-6 (IF 1.541)
Tzika, E.D., Papadimitriou, V., Sotiroudis, T.G., Xenakis, A. (2004) Chemical and enzymatic oxidation of oleuropein: an EPR study. Chem. Phys. Lipids. 130, 61 (IF 3.329)
Lentza-Rizos, C., E. J. Avramides, Argyropoulou, A., Papadimitriou, V., Kokkinaki, K. (2000) Field Trials to Determinate Residues of Chlozolinate in Table Grapes. J. Agric. Food Chem, 48, 2522-2527 (IF 5.279)
Avramiotis, S., Papadimitriou, V., Cazianis, C.T., Xenakis, A (1998) EPR studies of proteolytic enzymes in microemulsions. Colloids and Surfaces Α, (1998) 144, 295-304 (IF 4.539)
Papadimitriou, V., Xenakis, A., C.T. Cazianis, F.N. Kolisis. (1997) Structural and catalytic aspects of cutinase at controlled hydration levels". Colloid Polym. Sci., 275, 609-616 (IF 1.931)
Papadimitriou, V., Xenakis, A., Cazianis, C.T., Stamatis, H., Egmond, M., Kolisis, F.N. (1996) EPR studies of cutinase in microemulsions. Ann. N.Y. Acad. Sci., 799, 275-280 (IF 4.728)
Papadimitriou, V., Petit, C., Cassin, G., Xenakis, A., Pileni, M.P. (1995) Lipase catalyzed esterification in AOT reverse micelles: A structural Study. Adv. Colloid Interface Sci., 54, 1-16 (IF 12.98)
Papadimitriou, V., Petit, C., Xenakis, A., Pileni, M.P (1994) Structural modification of reverse micelles due to enzyme incorporation studied by SAXS. Progr. Colloid Polym. Sci., 97, 226-228
Papadimitriou, V., Xenakis, A., Evangelopoulos, A.E (1993) Proteolytic Activity of various w/o Microemulsions as related to the Polarity of the reaction medium. Colloids Surf. B: Biointerfaces, 1, 295-303. (IF 5.268)
Papadimitriou, V., Xenakis, A., Lianos, P. (1993) Electric Percolation of Enzyme containing Microemulsions. Langmuir, 9, 912-915 (IF 3.882)
Xenakis, Α., Papadimitriou, V., Lianos, P., (1993)Enzyme-induced percolation of w/o microemulsions". Progr. Colloid Polym. Sci., (1993) 93, 370-372.

Book Chapters

Theochari, I., Xenakis, A., Papadimitriou, V.*, (2020). Nanocarriers for effective drug delivery. In Smart Nanocontainers (pp. 315-341). Elsevier.
Chatzidaki, M.D., Papadimitriou, V., Xenakis, A., (2019). Encapsulation of food ingredients by microemulsions. In Lipid-Based Nanostructures for Food Encapsulation Purposes (pp. 129-149). Academic Press.
Xenakis, A., Papadimitriou, V., Stamatis, H. and Kolisis F.N. “Biocatalysis in microemulsions”, in Microemulsions: Properties and Applications, Surfactant Science Series, Edited by Mozner Fanun, CRC Press, Taylor & Francis Group (2009) pp 349-385.