Since 2013, HPDST has implemented three funded research projects:
- Project DACALBO - Digital Archive Concerning Alchemy in Byzantium and in Greek-Speaking Communities of the Ottoman Empire, which aimed at studying the history of Greek alchemy (manuscripts, sources, metadata, database of alchemical recipes, alchemy-society relations, educational applications of the history of alchemy). The project was funded by the Action THALES, NSRF 2007-2013, and was implemented from 2012 to 2015.
- the project NARSES - Nature and Religion in South Eastern European Space, which aimed at studying the relations between the Greek Orthodox Christians and Science from the end of Antiquity until the 20th century. The project was funded by the Action ARISTEIA, NSRF 2007-2013, and was implemented from 2012 to 2015.
- The project SOW - Science and Orthodoxy around the World, which aimed at studying the relationship between Orthodox Christianity and sciences all over the world with collaborators from 11 countries (Georgia, Bulgaria, Greece, Romania, Russia, Serbia, as well as Australia, Canada, France, Germany and the United States of America). The project was funded by the Templeton World Charity Foundation Inc. and was implemented from 2016 to 2019.
HPDST has implemented 14 research projects with Greek and European partners, has organized the collections of a Science Museum and has created a prominent scientific exhibition on the Antikythera Mechanism which was presented in eight foreign countries (Europe and China).