SCIENTIFIC PUBLICATIONS IN PEER-REVIEWED JOURNALS SUPPORTED BY DRUGDESI
2010
Felfoldi, N., Toth, M., Chrysina, E.D., Charavgi, M-D., Alexacou, K-M., Somsak, L. (2010). Synthesis of new glycosyl biuret and urea derivatives as potential glycoenzyme inhibitors. Carbohydrate Res. 345, 208-213.
2009
Chrysina, E.D., Bokor, E., Alexacou, K-M., Charavgi, M-D., Oikonomakos, G.N., Zographos, S.E., Leonidas, D.D., Oikonomakos, N.G., Somsak, L. (2009). Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case. Tetrahedron Asymm. 20, 733-740.
Benltifa, M., Hayes, J.M., Vidal, S., Gueyrard, D., Goekjian, P.G., Praly, J-P*, Kizilis, G., Tiraidis, C., Alexacou, K-M., Chrysina, E.D.*, Zographos, S.E., Leonidas, D.D., Archontis, G. and Oikonomakos, N.G. (2009). Glucose-based Spiro-isoxazolines: A New Family of Potent Glycogen Phosphorylase Inhibitors. Bioorg. Med. Chem. 17, 7368-7380.
Potamitis, C., Zervou, M., Katsiaris, V., Zoumpoulakis, P., Durdagi, D., Papadopoulos, M.G., Hayes, J.M., Gradolnik, S.G., Kyrikou, I., Argyropoulos, D., Vatougia, G., Mavromoustakos, T. (2009). Antihypertensive Drug Valsartan: Conformational Analysis, Dynamic NMR Spectroscopy, in silico Docking and Molecular Dynamics Studies. J. Chem. Inf. Mod. 49, 726-739.
Dossi, K., Tsirkone, V.G., Hayes, J.M., Matousek, J., Pouckova, P., Soucek, J, Zadinova, M, Zographos, S.E., Leonidas, D.D.* (2009) Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors. Eur. J. Med. Chem. 44, 4496-4508.
Zographos, S.E., Leonidas, D.D., Alexacou, K.M., Gimisis, T., Hayes, J.M., Oikonomakos, N.G.*, Wen, X., Sun, H., Liu, J., Cheng, K., Zhang, P., Zhang, L., Hao, J., Zhang, L., Ni, P. (2008) Pentacyclic Triterpenes Inhibitors of Glycogen Phosphorylase as Potential Drugs for Type 2 Diabetes: X-ray Crystallographic Studies, Planta Medica 74, 1146-1147.
Somsak, L.*, Czifrak, K., Toth, M, Bokor, E., Chrysina, E.D., Alexacou, K-M, Hayes, J.M., Lazoura, E., Leonidas, D.D., Zographos, S.E., Oikonomakos, N.G.* (2008). New Inhibitors of Glycogen Phosphorylase as Potential Antidiabetic Agents. Current Medicinal Chemistry 15, 2933-2983.
Alexacou, K.M., Hayes, J.M., Tiraidis, C., Zographos, S.E., Leonidas, D.D., Chrysina, E.D., Archontis, G., Oikonomakos, N.G.*, Paul, J.V., Varghese, B., Loganathan D* (2008). Crystallographic and computational studies on 4-phenyl-N-(b-D-glucopyranosyl)-1H-1,2,3-triazole-1-acetamide, an inhibitor of glycogen phosphorylase: Comparison with a-D-glucose, N-acetyl-b-D-glucopyranosylamine and N-benzoyl-N-b-D-glucopyranosyl urea binding. Proteins: Structure, Function & Bioinformatics 71, 301-307.
Manuscripts in preparation
Cismas, C., Hayes, J.M., Sovantzis, D., Hadjiloi, T., Mamais, M., Lazoura, E., Grammatopoulos, P., Stathis, D., Zographos, S.E., Leonidas, D.D., Oikonomakos, N.G., Gimisis, T., Chrysina, E.D. Synthesis, x-ray, and computational studies of b-D-glucose pyrimidine derivatives as glycogen phosphorylase inhibitors: the role of ligand ionization/tautomeric states examined.
Nagy, V., Felfoldi, N., Praly, J-P., Docsa, T., Gergely, P., Chrysina, E.D., Tiraidis, C., Kosmopoulou, M., Alexacou, K.M., Konstantakaki, M., Leonidas, D.D., Zographos, S.E., Hayes, J.M., Oikonomakos, N.G., Somsak, L. N-(4-substituted-benzoyl)-N'-(b-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation.
Chrysina, E.D., Nagy, V., Felfoldi, N., Telepo, K., Praly, J-P., Docsa, T., Gergely, P., Alexacou, J-M., Leonidas, D.D., Zographos, S.E., Oikonomakos, N.G., Somsak, L. Synthesis, kinetic and crystallographic evaluation of N-acyl-N'(b-D-glucopyranosyl)ureas, nanomolar glucose analogue inhibitors of glycogen phosphorylase, potential antidiabetic agents.
