Project overview

The major objective of MACROGENEX is to carry out multidisciplinary research and to develop competence in the field of structure, function and interplay of selected macromolecular assemblies participating in regulated gene expression, namely: (A) the TFIID basal transcription complex and its interactions with members of the AP-1 family of transcription factors, (B) the TAC (TBP-TFIIA-containing) transcription complex and its putative involvement in nuclear receptor regulation of cell proliferation and differentiation and, (C) the involvement of the specific transcription factor TAFII68 (TAF15) in novel multi-protein complexes. The participation of these structurally distinct complexes in a highly coordinated cross-talk with a wide range of components that function at the chromatin level to couple transcription initiation and elongation with post-transcriptional events is envisaged. To unravel such intricate interactions we rely on the research competence of the Host Researchers involved in the project, as well as on technology and knowledge transfer from incoming Marie-Curie fellows and two Partner Laboratories with competence in this field, namely the Labs of Drs. L. Tora (CNRS, Strasbourg) and H. G. Stunnenberg (Radboud Univ., Nijmegen).