EUROSTRUCT seeks to unravel the research potential of Structural Biology and Chemistry Group (SBCG) and the Institute of Biology, Medicinal Chemistry and Biotechnology, Division of Organic & Medicinal Chemistry (OMC) of the National Hellenic Research Foundation by creating a centre of excellence in structural biology, in Greece, with emphasis on structure-based drug design and discovery. This can be achieved through setting up a state-of-the-art X-ray and computational facility, recruitment of incoming experienced researchers, exchange of know-how and experience through trans-national two-way secondments of research staff, organisation of workshops and conferences to facilitate knowledge transfer at regional, national and international level, and through dissemination and promotional activities. The EUROSTRUCT project aims to build a critical mass of sustainable research capacity. In so doing, it will support researchers to tackle pressing health problems and deliver health benefits for people. The focus is on people and providing them with the training, mentoring and research environment that they need in order to answer compelling questions about health and disease. The scientists participating in this application provide the appropriate scientific environment for high quality training of the people engaged in the project. The EUROSTRUCT is intended to give recipients the freedom and flexibility to pursue new avenues of discovery and higher-risk research projects that hold potential for advancing significantly determination of three-dimensional structure of target proteins and structure-based drug discovery.