5th Clusterin/Apolipoprotein (CLU) Workshop

Scientific Programme
Monday, June 02	18:30 - 21:00	Registration (Spetses Hotel)
	21:00	Welcome Reception (Spetses Hotel) - Partially Sponsored by Bio-Rad (http://www.bio-rad.com)
Tuesday, June 03	08:00 - 09:00	Registration (Spetses Hotel)
	09:00 - 09:15	Welcome	Ioannis Trougakos
			Stathis Gonos
09:15 - 11:05	*Session (I): Cancer - Apoptosis, (I)*
		Chairs
	Andrei Thomas - Tikhonenko & Arturo Sala
	09:15 - 09:45	Saverio Bettuzzi :"A novel transgenic model for prostate cancer displays the tumor-suppressor activity of Clusterin" [Abstr. No S/02]
	09:45 - 10:15	David Boothman :"DNA damage-inducible Clusterin expression: a sensitive measure of genomic instability" [S/04]
	10:15 - 10:45	Ioannis Trougakos :"Clusterin functions intracellularly by conferring stability to both organelle structure and the cytoplasmic ku70-bax complex" [S/20]
	10:45 - 11:05	Ioannis Trougakos :"Signalling pathways regulated by Clusterin in human cancer cells" [S/21]
	11:05 - 11:30	Coffee break
11:30 - 13:15	*Session (II): Chaperone activity - Neurological Diseases*
		Chair
	Arkadiusz Orzechowski
	11:30 - 11:45	Amy Wyatt :"Establishing an in vivo role for Clusterin in clearing misfolded extracellular proteins" [S/22]
	11:45 - 12:15	Amy Wyatt :"The role of clusterin in extracellular protein quality control" [S/23]
	12:15 - 12:45	Jeong Hun Kim :"The protective role of Clusterin in retinal angiogenesis " [S/08]
	12:45 - 13:15	Ofer Levy : "Computational design and experimental confirmation of a peptide that targets secreted Clusterin" [L1]
	13:15 - 16:00	Lunch / Free time
16:00 - 18:00	*Session (III): Protein trafficking and proteolysis*
		Chairs
	Saverio Bettuzzi & Claudia Koch-Brandt
	16:00 - 16:30	Federica Rizzi :"Clusterin is a short half-life, poly-ubiquitinated protein which controls the fate of prostate cancer cells" [S/14]
	16:30 - 17:00	Steffen Roth :"Quantitative Clusterin ELISA" (http://www.biovendor.com) [S/15]
	17:00 - 17:30	Amina Zoubeidi :"Clusterin is ubiquitin binding protein that facilitates COMMD1 and I-kB degradation to enhance NF-kB activity" [S/25]
	17:30 - 18:00	Stathis Gonos :"Clusterin/Apolipoprotein J as an ageing biomarker" [S/07]
	18:00 - 18:30	Coffee break
Keynote Lecture	18:30 - 19:30	Richard Youle :"Roles of the bcl-2 family proteins in apoptosis" [S/24]
	20:00	Workshop Dinner at a Fish Tavern
Wednesday, June 04
09:00 - 10:30	Session (IV): Cancer - Apoptosis, (II)
		Chairs
	Stathis Gonos & Julie Djeu
	09:00 - 09:30	Julie Djeu :"Resistance to trail and docetaxel via a common mechanism involving Clusterin" [S/05]
	09:30 - 10:00	Evangelos Kolettas :"Vanadium-induced apoptosis of HACAT cells is mediated by c-fos and involves up-regulation of nuclear Clusterin / apolipoprotein J" [S/10]
	10:00 - 10:30	Beata Pajak :"The role of Clusterin in the resistance of human colon adenocarcinoma cells to TNF-alpha-induced apoptosis" [S/11]
	10:30 - 11:00	Coffee break
11:00 - 12:30	**Session (IV): Cancer - Apoptosis, (II)* (continued)***
		Chairs
	David Boothman & Ioannis Trougakos
	11:00 - 11:30	Francesca Panico :"Role of Clusterin in normal or tumoral bronchial human cells exposed to cigarette smoke" [S/12]
	11:30 - 12:00	Arturo Sala :"ApoJ/Clusterin is a novel haploinsufficient neuroblastoma suppressor gene negatively regulated by mycn" [S/16]
	12:00 - 12:30	Thomas-Tikhonenko Andrei :"Regulation of Clusterin by myc-regulated microRNAs" [S/19]
	12:30 - 15:00	Lunch / Free time
15:00 - 16:30	*Session (V): Protein Interactions - Signalling*
		Chairs
	In-Sun Park & Gilles Chiocchia
	15:00 - 15:30	Sabina Pucci :"IL-6, VEGF-A, sClusterin: a prosurvival molecular network in colon carcinogenesis" [S/13]
	15:30 - 16:00	Gianluca Baccheschi (Bio-Rad) :"Novel multiplexing approaches for protein quantification and protein interaction studies. Get much more with less sample" (http://www.bio-rad.com) [S/01]
	16:00 - 16:30	Fabiola Sesti :"Clusterin and IL-6: a new twin set of non-invasive molecular markers for colorectal cancer detection" [S/17]
	16:30 - 18:00	Poster Session (12 Posters)
	18:00 - 18:15	Coffee break
18:15 - 20:05	*Session (V) (continued)*
		Chairs
	Beata Pajak & Bon-Hong Min
	18:15 - 18:45	Abdellatif Essabbani :"Clusterin and NF-kB pathway regulation" [S/06]
	18:45 - 19:15	Young-Jun Shim :"Clusterin elicits a mitogenic effect on astrocytes via EGFR-ERK pathway" [S/18]
	19:15 - 19:35	Claudia Koch-Brandt: "Expression of Apolipoprotein J in vascular smooth muscle cells is induced through TLR3 by RNA released from necrotic cells" [S/09]
	19:35 - 20:05	David Boothman :"Transforming growth factor-b1 induction of the insulin-like growth factor-1-secretory Clusterin (IGF-1-SCLU) expression axis" [S/03]
	20:05 - 20:20	Discussion about Clusterin isoforms nomenclature
	20:20 - 20:30	Summary and Workshop ending
	21:00	Gala Dinner at the Old Harbour – Partially Sponsored by BioVendor GmbH (http://www.biovendor.com)
Thursday, June 05		*Departure*