INSTITUTE OF BIOLOGY, MEDICINAL CHEMISTRY & BIOTECHNOLOGY
 
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Structural Biology & Chemistry

Funding (2005-Present)

  • PREVENT: Molecular, functional and structural analysis of Mosquito OBPs for Prevention of Vector-Borne Infectious Diseases” General Secretariat for Research and Technology, Research grant ESPA R&D project of bilateral cooperation Greece-Turkey 2013-2014 in collaboration with Ass. Prof. M. Senay Sengul, Department of Molecular Biology and Genetics, Gaziosmanpasa University, Tokat, Turkey (2014-2015). Coordinator Dr. S. E. Zographos, IBMCB/NHRF. Budget: 30,000 €.

  • ''STHENOS: Targeted therapeutic approaches against degenerative diseases, with emphasis on cancer and aging’’ Ministry of Education, Lifelong Learning, and Religious Affairs,  “Development Proposals of Research Institutions - KRIPIS”, NSRF 2007-2013. O.P. “Competitiveness & Entrepreneurship” and Regions in Transition” (1/1/2013-31/12/2015); Coordinator Dr. A. Pintzas (IBMCB Director), IBMCB/ NHRF. Budget Total/for SBCT: 1,500,000/120,000 €.

  • «Instruct-Ellas, National consortium». Access to large scale synchrotron radiation facilities in the frame of “BioStruct-X” April 2012-2013 & 2013-2014; Coordinator: Dr E.D. Chrysina) (for users’ visits to Synchrotron Radiation Source-EU Large scale facilities with accommodation and travel expenses)

  • «Greek network of protein crystallographers». Access to large scale synchrotron radiation facilities in the frame of “BioStruct-X” April 2013-2015; Coordinator: Dr G. Kontopidis, PI S.E. Zographos) (for users’ visits to Synchrotron Radiation Source-EU Large scale facilities with accommodation and travel expenses)

  • “Advanced research for Mosquito Repellents” Project Number 227764. Access to Structural Proteomics Facility OPPF, Rutherford Appleton Laboratory, Harwell Research Complex, Oxford, UK. (2012). FP7 Capacities Specific Programme Research Infrastructures, “P-CUBE” (Infrastructure for Protein Production Platforms), (P.I. Dr S.E. Zographos)

  • «Optimization of human brain glycogen phosphorylase expression» Trans-national Access award to visit Structural Proteomics Facility OPPF, Rutherford Appleton Laboratory, Harwell Research Complex, Oxford, UK. FP7 Capacities Specific Programme Research Infrastructures, “P-CUBE” (2011) (Infrastructure for Protein Production Platforms) (P.I. Dr. E.D. Chrysina)

  • «Synthesis, kinetic and crystallographic studies of potential inhibitors targeting glycogen phosphorylase», (2010-2013) HERAKLEITOS ΙΙ (Coordinator: A. Gimisis, Univ. of Athens, PI Dr ED Chrysina) Budget Total/for SBCT: 40,000/20,000 €.

  • «Molecular, structural and catalytic studies of novel biocatalysts (hemicelluloses) implicated in plant biomass degradation», (2010-2013) HERAKLEITOS ΙΙ (Coordinator: P. Christakopoulos, NTUA, PI Dr ED Chrysina) Budget Total/for SBCT: 40,000/13,500 €.)

  • ''ARCADE: Advancement of Research Capability for the Development of New Functional Compounds'' FP7-REGPOT-2009-1, (GA-245866), (01/12/2009-30/5/2013); Coordinator Dr. B. Steele, IBMCB/NHRF. Budget Total/for SBCT 2,000,000/205,000 €.
    http://www.arcade- iopc.eu

  • ''ENAROMaTIC: European Network for Advanced Research on Olfaction for Malaria Transmitting Insect Control.'' FP7-HEALTH-2007-2.3.2-9, (GA-222927), (1/12/2008-30/11/2012); Coordinator Dr. K. Iatrou, NCR Demokritos. PI Dr. S. E. Zographos. Budget Total/for PI: 2,500,000/280,000 €. http://www.enaromatic.org/.

  • ''EUROSTRUCT: European consolidation and promotion of research capacity in the area of structure based drug discovery''. FP7-REGPOT-2008-1, (GA-230146), (1/2/2009-31/1/2012); Coordinator Dr. S.E. Zographos, IBMCB/NHRF. Budget: 970,300 €.
    http://www.eie.gr/nhrf/institutes/iopc/eu-projects/eurostruct/index-en.html.

  • EURORES: European Researchers’ Night in Greece” FP7-PEOPLE-NIGHT-2008, CN-22, (2008). Coordinator Dr. N.G. Oikonomakos, NHRF. Budget: 50,000 €.

  • «GPdia – A multidisciplinary investigation towards inhibitors of glycogen phosphorylase designed and evaluated as antidiabetic molecules» French Agence Nationale de la Recherche (ANR) (coordinator: Dr Jean-Pierre Praly, Université Claude-Bernard Lyon 1) (the project was supported through the French partner and travel expenses for Dr E.D. Chrysina).

  • "Protein complexes of CINAP: composite molecular targets for the understanding of human disease". Cyprus Research Promotion Foundation, Thematic Research Grant YGEIA, GA-0506/05 (2007-2009). Coordinator Prof. N. Santama, University of Cyprus. PI S. E. Zographos. Budget Total/for PI: 135,097 /16,879 €.

  • DRUGDESI: Drug design at the molecular level using approximate and exact computational methods” Marie Curie Host Fellowships for the Transfer of Knowledge, MTKD-CT-2006-042776 (2007-2011). Coordinator: N.G. Oikonomakos/ E.D. Chrysina since Sept. 2008, NHRF. Budget: 186,396.40 €.

  • “Inhibitors of glycogen phosphorylase and phosphorylase kinase as potential antidiabetic drugs” Greek General Secretariat for Research and Technology, Research grant ENTER 2004, GA-04ER 70 (2006-2008). Coordinator Dr. N. Oikonomakos, NHRF. Budget: 78,000 € (Business Partner Pfizer Inc, Pfizer Global Research & Development, Groton Laboratories, USA; Contribution 8,000 €)

  • EURODESY: A European Research Training Site for the Design and Synthesis of Novel Neuroprotective and Hypoglycaemic Agents through a Multi-disciplinary approach” Marie Curie Early Stage Training (EST), MEST-CT-020575 (2006-2010). Coordinator Dr. N.G. Oikonomakos, Director IOPC. Sub-coordinators Dr. D. Leonidas and Dr. I. Kostas, all research groups of IOPC/NHRF participate in the network along with the Molecular Endocrinology group of IBRB/NHRF). Budget: 984,182 €.

  • “A Training, Implementation and Discrimination (TID) centre (Heraklion TID-Centre) of the EU project «BIOXHIT». BIOXHIT stands for Biocrystallography (X) on a Highly Integrated Technology Platform for European Structural Genomics and is funded under the FP6 of the EC (LSHG-CT-2003-503420) (2006-2008). Coordinator for Heraklion TID-Centre: Dr. K. Petratos, Institute of Molecular Biology and Biotechnology, Crete. Budget: 60,000 €. Role: Collaborators (co-organizer of the international workshop entitled “From Crystals to Structures: Crystallization, Diffraction Data Collection, Processing and Phasing” 23-25 June 2008, IMBB-FORTH, Crete, Greece).

  • “Crystallisation, co-crystallisation, and crystallographic studies with human pancreatic glucokinase, a molecular target for types 2 diabetes therapy» by Aventis Pharma Deutschland GmbH, a company of the sanofi-aventis group, Frankfurt, Germany (2005-2006); Coordinator Dr. N. Oikonomakos Budget: 10,000 €.

  • “Structure-function relationship of TAF9 proteins” Human Resources and Mobility activity, Marie Curie European Reintegration Grant, MERGE-CT-2004-006358, (2004-2005); Coordinator Dr. S. E. Zographos. Budget: 40,000 €.

  • “Structure/function relationships of recombinant human TAFs9 proteins” Greek General Secretariat for Research and Technology, Research Grant ENTER 2001, GA-01ER 115 (2004-2006). Coordinator Dr. N.G. Oikonomakos, Reintegrated researcher: S. E. Zographos. Budget: 65,588

  • “Structure/function relationships of new human protein CIP1 with molecular pathogenesis of neurodegenerative disorders”. Cyprus Research Promotion Foundation, Research Grant PENEK 2004-2005, ENISX 0603/03 (2004-2006). Coordinator Prof. N. Santama, University of Cyprus. PI S. E. Zographos. Budget Total/for PI: 60,000/3,595 €.

  • “Discovery of small-molecule inhibitors of glycogen phosphorylase, as potential hypoglycaemic agents, guided by structure-based drug design and in silico virtual ligand screening" Greek General Secretariat for Research and Technology (EPAN) Research Grant for Scientific and Technological cooperation between Greece and USA, Prof. Alexander D. MacKerell, Jr., Computer-Aided Drug Design Center, School of Pharmacy, Univ. of Maryland, Baltimore, MD, USA (USA 046) (2004-2006). Coordinator Dr. N. Oikonomakos, NHRF. Budget: 60,000 €.

  • “Structure-based design of new potential hypoglycaemic drugs” General Secretariat for Research and Technology, Research grant EPAN R&D project of bilateral cooperation Greece-Hungary in collaboration with Prof. László Somsák, Department of Organic Chemistry, University of Debrecen, Hungary (2004-2006). Coordinator Dr. N. Oikonomakos, NHRF. Budget: 11,740 €.

  • “Crystallisation and preliminary crystallographic studies on human phosphoenolpyruvate carboxykinase, a molecular target for types 2 diabetes therapy”. Supported by Pfizer Inc. (2003-2005) (PI. Dr. N.G. Oikonomakos/NHRF), Budget: €8,000.

  • «Calmodulin regulated protein kinases: molecular and cellular functions of five prototypic members from the human genome by a multidisciplinary approach». HPRN-CT-2002-00252/EU Research Network (Coordinator Dr. M. Wilmanns, EMBL, Hamburg Unit; participants Prof. L.N Johnson, FRS Univ. of Oxford, Prof. Adi Kimchi, Weizmann Inst. of Science, Prof. Mathias Gautel, King’s College London, UK, N.G. Oikonomakos (PI), NHRF, Prof. Mauno Vihinen, Univ. of Tampere) (2002-2006), € 200.000.

  • «Glycogen phosphorylase as molecular target for the development of new potent hypoglycaemic drugs» PENED 2001/GSRT (coordinator Dr. N.G. Oikonomakos/NHRF, Business partner Aventis Pharma Deutsland GmbH) (2002-2005), Budget: €128,187.82.

  • European Structural Biology Forum (ESBF)-to a European infrastructure cooperation network/EU (2001-2005). An Infrastructure Cooperation Network (coordinated by Prof. Rolf Hilgenfeld, P.I. Dr. N.G. Oikonomakos/NHRF) with 10 European Research Infrastructures, 8 Users, and Bruker GmbH, Karlsruhe, Germany, Travel grants. Bugdet: €11,200

 

Funding for Transnational access to EU large scale facilities 2005-Present:

All members of SBCT are registered users of Large Scale Facilities for structural studies using Synchrotron Radiation Sources including:

  • Synchrotron Radiation Source CCLRC Daresbury Laboratory, UK
  • EMBL Hamburg Outstation, Germany
  • MAX-lab, Lund, Sweden

They have regular access (at least twice per year each) to these facilities and their travel and accommodation expenses have been covered by FP6 and FP7 Research Infrastructure Actions “Structuring the European Research Area”, ‘‘ELISA’’ (European Light Sources Activities; 2005-2010) and BioStruct-X (Collaborative projects and Coordination and Support Actions 2011-Present).

 


 
 

 

 

 

 
 

 

   
       

 

 

National Hellenic Research Foundation (NHRF), 48 Vassileos Constantinou Ave., 11635 Athens, Greece, Tel. +302107273700, Fax. +302107246618